Uptober crypto is coming, and then Movember. Seasonality usually triggers a 30% to 50% gain during these two months. But what cryptocurrency is likely to 5x over the next six months?
Just because
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Bitcoin
0.76%
Bitcoin
BTC
Price
$113,007.48
0.76% /24h
Volume in 24h
$54.01B
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or
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Ethereum
1.36%
Ethereum
ETH
Price
$4,160.08
1.36% /24h
Volume in 24h
$30.59B
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had some exponential growth relative to another coin doesn’t mean no other coin can ever have that kind of growth. This reminds me of those times five years ago when people laughed that BTC would ever go above $3000, and yet here we are!
The point is, past performance isn’t an indicator of future action when it comes to the shitshow we call crypto. So here are five coins in the top 100: SEI Crypto, SUI, Hyperliqud, Avalanche, and Solana, and their chances to 5x in six months.
Uptober Crypto #1: Does SEI Crypto Have The Best Upside?
Among small-cap layer-1s, Sei (SEI) appears to be the wildcard. Wallets jumped 76% to 8.3M in a single month, while daily active addresses hit a record 670,000, according to CoinCentral. DeFi volumes are surging too, with $9.88Bn traded in late September.
Catalysts are lining up with a 21Shares ETF filing that could materialize in 2026. Sei’s parallelized engine also makes it ideal for order-book DEXs.
But the risks are clear. The fully diluted valuation already sits in the low billions, and upcoming unlocks in 2026 could have a significant impact.
Odds: Most speculative shot at 5×, but hinges on ETF approval and timing a bull run.
DISCOVER: Top 20 Crypto to Buy in 2025
#2 Can Sui Turn Strong Adoption Into a 5× Return?
Sui (SUI) has the fundamentals that many L1s lack and a huge influencer backing through Raoul Pal and Real Vision Finance. In the first half of 2025, it processed 2.7Bn transactions, with daily activity averaging ~1N addresses at its peak. DeFi Llama shows TVL holding above $1Bn, with liquid staking pushing the total closer to $3.4Bn.
A $1.7Bn market cap, a 5× would demand billions in new inflows. It’s not impossible, but a stretch in six months.
SUI Odds: Strong usage, but more likely a 2–3× in six months.
DISCOVER: 20+ Next Crypto to Explode in 2025
Uptober Crypto #3: Is Hyperliquid Already Too Big for Explosive Gains?
The perpetual DEX Hyperliquid (HYPE) is one of crypto’s fastest-growing revenue machines. By July 2025, trading volume topped $320Bn, generating $86.6M in protocol revenue, with TVL surpassing $5Bn. Daily users are in the hundreds of thousands.
With Aster Crypto now as a competitor, it certainly limits the ceiling for Hyperliquid.
Hyperliquid Odds: Revenue giant, yet valuation limits upside.
DISCOVER: Next 1000X Crypto: 10+ Crypto Tokens That Can Hit 1000x in 2025
#4 Does Avalanche Still Have Room to Run?
Avalanche (AVAX) has regained relevance through the introduction of subnets and the tokenization of real-world assets. Daily transactions average 18.5M, up more than 200% quarter-over-quarter, with TVL near $2.8Bn, according to DefiLlama.
#Avalanche DEXs are in full flight..volume is back at 2021 highs! Who’s buckled up for the @avax autumn lift-off?!#AVAX pic.twitter.com/Kd7xgYXArQ
— COLONY
(@Colonylab) September 30, 2025
With a $12Bn market cap, a 5× would mean $60Bn, which is unlikely without a frenzy of capital rotation. Unlocks remain a risk, even as DeFi and gaming adoption climb.
AVAX Odds: Solid growth, but mid-cap size caps returns.
Uptober Crypto #5: Is Solana Now Too Large for Outsized Returns?
Solana (SOL) is entrenched as a top-five asset. More than 2.2M wallets are active daily, with transaction costs averaging $0.00025. SOL is the truth.
At an $85 billion market cap, however, a 5× would push Solana into the trillions, which, for now, is only reserved for Bitcoin and Ethereum.
Solana Odds: Blue-chip status makes 5× nearly impossible.
Who’s Ready for Uptober? What the Numbers Say About 5× Potential
I expect a good Uptober just as has happened in ten of the twelve years that Coinglass tracks.
Both negative years occurred two years after halving, in the midst of what is known as Cryptowinter. This year is one year post-halving, and historically has been up around 40%.
99Bitcoins analysts won’t be surprised at a major drop starting in late November or December, because the global economy is for sh*t right now. According to CoinGecko, only three of the top 100 tokens have managed a 5× gain within any six-month window since 2021, and all were small-caps under $1 billion.
For now, it’s full steam ahead. These coins are some of your safest picks, and we predict at least one of them will manage a near 5x gain.
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Key Takeaways
- Uptober crypto is coming, and then Movember. Seasonality usually triggers a 30% to 50% gain during these two months.
- 99Bitcoins analysts won’t be surprised at a major drop starting in late November or December, because the global economy is for sh*t right now.
The post Can Any Uptober Crypto Realistically 5× in Six Months? A Breakdown of SEI, SUI, Solana, Hyperliquid, and Avalanche appeared first on 99Bitcoins.
